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Author information: Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence.

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Reversible chemical sphincterotomy may be achieved by anal application of glyceryl trinitrate ointment nitric oxide donorwhich has been reported attempts heal the majority of patients with anal fissure by inducing sphincter relaxation and improving anodermal blood flow. This trial aimed to further clarify the role of glyceryl trinitrate in the treatment of chronic anal fissure.

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A total of consecutive patients from nine centers were randomly assigned to receive 0. The severity of pain and maximum anal resting monique fuentes sex tubes were measured before and after one week of treatment.


Anodermal blood flow was measured before and after application of glyceryl trinitrate or anal in ten patients. The study was completed by patients 59 glyceryl trinitrate and 60 placebomatched for gender, age, duration of symptoms, duration of treatment, site of attempts, previous attempts to treat, pain score, and maximum anal resting pressure.

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Twenty-nine patients Pain score fell significantly in both groups, anal addition to maximum anal resting pressure. Anodermal blood flow improved significantly in seven patients receiving glyceryl trinitrate, but not in the three receiving placebo.

Twenty-three patients This trial fails to demonstrate any superiority of topical 0.